Research Awards

2005 – Today

Endothelial Genomics and Phenotype in Early Atherosclerosis – Robert Hebbel, M.D., UMN; Amir Lerman, M.D., Mayo

Coordinated Multi Program Utilization of Microarray Data to Generate and Validate Biomarkers for Improved Care of Patients with Prostate Cancer – Donald Connelly, M.D., Ph.D., UMN; George Klee, M.D., Ph.D., Mayo

Proteomic Design of Peptide-Based Probes for the Molecular Imaging of Amyloid Plaques to Diagnose Alzheimer’s Disease Using Contrast-Enhancement Magnetic Resonance at High Field Strength (9.4T)  – Michael Garwood, Ph.D., UMN; Joseph Poduslo, Ph.D., Mayo

Non-Volitional Activity in Obesity Resistance: Role of the Brain – Catherine Kotz, Ph.D., UMN; James Levine, M.D., Ph.D., Mayo

Development of Ultra-Small Sensors for Accurate Quantification of Muscle Forces in Neuromuscular Diseases –  Rajesh Rajamani, Ph.D., UMN,; Kenton Kaufman, Ph.D., Mayo

Neuro-Oncology Genetics – David A. Largaespada, Ph.D., UMN; Robert B. Jenkins, M.D., Ph.D., Mayo

Selective, Small-Molecule Inhibitors of JNK2 as Anti-Cancer Drugs – Zigang Dong, M.D., Ph.D., UMN; Yuan-Ping Pang, Ph.D., Mayo

Medical Genomics Applied to an Ancient Disease: Real-time PCR for the Diagnosis and Direct Drug Susceptibility Testing of Tuberculosis – Dean Tsukayama, M.D., UMN; Nancy Wengenack, Ph.D., Mayo

Biomarker Discovery in Autoimmunity – Timothy W. Behrens, M.D. (changed to Emily Gillespie as of 11.30.06), UMN; Ann M. Reed, MD (changed to Erik Peterson, M.D., Mayo 6.26.06)

Combinatorial Based Chemistry and High Throughput Screening Methods to Identify Rac GTPase Inhibitors – Steven E. Patterson, Ph.D., UMN; Daniel D. Billadeau, Ph.D., Mayo

Identifying factors influencing the survival of kidney allografts by genomic and protemic analysis – William Oetting, Ph.D., UMN; Fernando G. Cosio, M.D., Mayo

Towards a Gene Therapy for Cocaine Addiction – Marilyn E. Carroll, Ph.D., UMN; Stephen Brimijoin, Ph.D., Mayo

Progenitor Cells as Biomarkers: Developing Diagnostic and Prognostic Profiles for Cardiovascular Disease – Doris Taylor, Ph.D.,UMN; Amir Lerman, M.D., Mayo

Development of Antibody Fragments as Contrast Agents for MR Imaging of Alzheimer’s Disease Amyloid Plaques – Michael Garwood, Ph.D., UMN; Joseph Poduslo, Ph.D., Mayo

Validation of Magnetic Resonance Techniques as Measures of Therapeutic Efficacy for Drug Discovery in Alzheimer’s Disease – Michael Garwood, Ph.D., UMN; Clifford R. Jack, Jr., M.D., Mayo

Predicting Alzheimer’s Disease – Karen Ashe, M.D., Ph.D., UMN; Ronald Petersen, M.D., Ph.D., Mayo

The Identification and Validation of miRNA Signature Profiles as Biomarkers for Colon Cancer Progression – Clifford J. Steer, M.D., UMN; Stephen Thibodeau, Ph.D., Mayo

Minnesota Partnership for Translational Nanotechnology in Cancer – Stephen C. Ekker, Ph.D., UMN; Debabrata Mukhopadhyay, Ph.D., Mayo

Targeting Human LEDGF/p75 and APOBEC3G for Treatment of HIV/AIDS – Reuben Harris, Ph.D., UMN; Eric M. Poeschla, M.D., Mayo

Design and Characterization of Novel Natriuretic Peptides for the Treatment of Congestive Heart Failure – Lincoln Potter, Ph.D., UMN; John Burnett, M.D., Mayo

Therapeutic Targets for Atopic Dermatitis – Douglas Plager, Ph.D., UMN; Sheila M.F. Torres, D.V.M., Ph.D., DACVD, Mayo

High Resolution Spatio-temporal Functional Neuroimaging in Epilepsy – Bin He, Ph.D., UMN; Gregory A. Worrell, M.D., Ph.D., Mayo

Virotherapy for Mesothelioma – Robert A. Kratzke, M.D., UMN; Stephen J. Russell, M.D., Ph.D., Mayo

Selective and Irreversible Inhibitors of Aphid Acetylcholinesterase as Human-Safe Pesticides for Controlling Soybean and Green Peach Aphids in Minnesota – David Ragsdale, Ph.D., UMN; Yuan-Ping Pang, Ph.D., Mayo

Identification and optimization of small molecular inhibitors of histone acetyltransfease Rtt109: A novel approach to prevent fungal infection – Judith G. Berman, Ph.D., UMN; Zhiguo Zhang, Ph.D., Mayo

Correction of Cardiomyopathy by Sleeping Beauty Mediated Transposition and In Vivo Selection – R. Scott McIvor, Ph.D., UMN; Stephen J. Russel, M.D., Ph.D., Mayo

Quantitative Vibro-Acoustography: A Novel Approach to Viscoelastic Tissue Characterization – Bojan Guzina, Ph.D., UMN; Mostafa Fatemi, Ph.D., Mayo

Development of New Carbon Nanotube Wireless Sensors for Respiratory Gas Exchange Analysis in Humans – Rajesh Rajamani, Ph.D., UMN; Bruce D. Johnson, Ph.D., Mayo

Small molecule screens for selective growth inhibitors in a yeast model of familial paraganglioma – Gunda I. Georg, Ph.D., UMN; Jim Maher, Ph.D., Mayo

Hydrogen Sulfide: From Toxic Molecule to Therapeutic Agent – Michael Levitt, M.D., UMN;  Joseph H. Szurszewski, Ph.D., Mayo

New Generation Oncolytic Adenovirus for Refractory Cancers – Masato Yamamoto, M.D., Ph.D., UMN; John C. Morris, III, M.D., Mayo

High-Resolution Nano-LAMP Microarrays to Measure the Binding Strength of Therapeutic Human Natural Auto-Antibodies on Target Cell-Surface Antigens – Sang-Hyun Oh, Ph.D., UMN; Moses Rodriguez, M.D., Mayo

Towards gene therapy of Friedreich Ataxia and other mitochondrial diseases – Michael D. Koob, Ph.D., UMN; Grazia Isaya, M.D., Ph.D., Mayo

Cell Therapy of Cardiac Arrhythmias – Robert T. Tranquillo, Ph.D., UMN; Douglas L. Packer, M.D., Mayo

Applying network theory to optimize cancer virotherapy – Claudia Neuhauser, Ph.D., UMN;  David Dingli, M.D., Ph.D., Mayo

Early predictors of autoimmunity and opportunities for intervention – Emily Baechler Gillespie, Ph.D., UMN; Ann M. Reed, M.D., Mayo

Validation of cyclophilin B as a therapeutic target in brain tumors – John R. Ohlfest, Ph.D., UMN; Richard J. Bram, M.D., Ph.D., Mayo

A Novel Cerebral Venous System Mapping and Ablation Technology to Treat Central Nervous System Disorders Including Epilepsy and Stroke – Bin He, Ph.D., UMN; Samuel J. Asirvatham, M.D., Mayo

Low-cost and high-performance nano-sensors: synthetic ion sensors for biological and medical applications – Tianhong Cui, Ph.D., UMN; Min-Hwang (Perry) Chang, Ph.D., Mayo

Development of a Novel Biocomposite Artificial Cornea – Allison Hubel, Ph.D., UMN; Sanjay Patel, M.D., Mayo

Novel Tissue Engineering of Patient-Specific Islet Cells for Diabetes Therapy – Jonathan Slack, Ph.D., UMN; Yasuhiro Ikeda, Ph.D., Mayo

Development of Antibodies for the Detection of Topoisomerase I- and Topoisomerase II-DNA Complexes – Daniel Harki, Ph.D., UMN; Scott Kaufmann, M.D., Ph.D., Mayo

Microfluidic Neurotechnology for Neuronal Survival and Regeneration – Sang-Hyun Oh, Ph.D., UMN: Moses Rodriguez, M.D., Mayo

Function of patient specific iPSC-derived endothelium – Dan Kaufman, M.D., Ph.D., UMN;  Robert Simari, M.D., Mayo

Cancer Drug Target discovery from genetic interactions – Chad Meyers, Ph.D., UMN; Dennis Wigle, M.D. Ph.D., Mayo

Selective Serotonin Re-uptake Inhibitor (SSRI) Pharmacogenomics in Patients with Major Depressive Disorder (MDD): Induced Pluripotent Cells (iPSC) as a Novel Model System for Functional Genomics after Genome-wide Association Studies (GWASs) – Jonathan Slack, Ph.D. / James R. Dutton, Ph.D., UMN; Richard Weinshilboum, M.D., Mayo

Myelodysplastic syndrome: Bench to Bedside – Jeffrey Miller, M.D., UMN; Mark Litzow, M.D., Mayo

Genomics of pancreatic cancer precursor lesions – diagnostic applications – Subbaya Subramanian, Ph.D., UMN: Fergus J. Couch, Ph.D., Mayo

Development of Multifunctional Nanoparticles to Diagnose and Treat Cerebral Amyloid – Angiopathy – Karunya K. Kandimalla, Ph.D., UMN; Joseph F. Poduslo, Ph.D., Mayo

Diagnosis and Tailored Treatment of APOBEC-Activated Ovarian Cancer – Reuben S. Harris, Ph.D., UMN; Scott Kaufmann, M.D., Ph.D., Mayo

Novel Therapeutic Agents for the Treatment of Glaucoma – Peter Dosa, Ph.D., UMN;          Michael P. Fautsch, Ph.D., Mayo

Early Detection of Alzheimer’s Disease Using Advanced MR Technology – Gulin Oz, Ph.D., UMN; Kejal Kantarci, M.D., Mayo

Functional Metabolomic Approach to Eradicate Tuberculosis – Anthony Baughn, Ph.D., UMN; Nicholas Chia, Ph.D., Mayo

Development of Novel Drugs for the Treatment of Gliomas – Lester R. Drewes, Ph.D., UMN;  Aaron J. Johnson, Ph.D., Mayo

Smart Socks for Tracking Health Status in Chronic Heart Failure – Rajesh Rajamani, Ph.D., UMN; Bruce Johnson, Ph.D., Mayo

Developing novel microbiota-targeted therapies for Irritable Bowel Syndrome – Dan Knights, Ph.D., UMN;  Purna Kashyap, M.B.B.S., Mayo

Manipulating plasma ghrelin for stress reduction and other therapeutic goals – Marilyn Carroll, Ph.D., UMN; Stephen Brimijoin, Ph.D., Mayo

TALEMs: Locus-specific Targeted Methylation Technology – Dan Voytas, Ph.D., UMN;             Stephen Ekker, Ph.D., Mayo

Genomic approach for targeted immunotherapy against ovarian cancer – Dan Kaufman, M.D., Ph.D., UMN;  Paul Haluska, M.D., Ph.D., Mayo

Improving Malaria Diagnostics using Thermal Contrast Reading of Lateral Flow Assays –    John Bischof, M.D., UMN; Bobbi Pritt, M.D., Mayo

Transcatheter Aortic Valve From Engineered Tissue – Bob Tranquillo, Ph.D., UMN; Amir Lerman, M.D., Mayo

Predicting response and resistance to proteasome inhibitors in multiple myeloma – Brian Van Ness, Ph.D., UMN; Shaji Kumar, M.D., Mayo

VSV-cDNA Library Therapy for Treatment of Glioblastoma in Domestic Dogs – Elizabeth Pluhar, D.V.M., Ph.D., UMN; Richard Vile, Ph.D., Mayo

Development of novel sGC activators to treat aortic valve calcification – Michael A. Walters, Ph.D., UMN; Jordan D. Miller, Ph.D., Mayo

Electroporation for Selective Cardiac and Extracardiac Tissue Ablation: Novel Therapies for Disease Involving Electrically Active Tissue – Paul Iaizzo, M.D., UMN; Samuel J. Asirvatham, M.D., Mayo

Abiraterone Acetate Pharmacogenomics – Scott Dehm, Ph.D., UMN; Manish Kohli, M.D., Mayo

Novel Oligonucleotides to Regenerate Myelin – Sang-Hyun Oh, UMN; Jim Maher, Mayo

Molecular Mechanism of Novel Small Molecule Therapeutics for Alzheimer’s Disease – Michael Lee, Ph.D.,  Dezhi Liao, Ph.D., UMN; Eugenia Trushina, Ph.D., Mayo

Bioengineered Oral Vaccines Agains Antibiotic-resistant Pathogens – Chun Wang, Ph.D., UMN; Michael Barry, Mayo

Smart Fabric for Cardio-performance Enhancement Based on Human Spacesuit Design – Lucy Dunne, Ph.D., UMN; Bruce Johnson, Ph.D.

Charcterization of Anti-tumor Immune Responses Following Oncolytic Virotherapy in Spontaneous Cancer – Jaime Modiano, V.M.D, Ph.D.,  UMN; Stephen Russell, M.D., Ph.D., Mayo

Evaluation of Novel Treatment Strategies for CTG Trinucleotide Repeat Diseases in Preclinical Models – Harry Orr, Ph.D., UMN; Mike Fautsch, Ph.D.,  Mayo

Early Diagnosis of Brain Insulin Resistance in Alzheimer’s Disease Patients and in Non-demented Elderly – Karunya Kandimalla, Ph.D.,  UMN; Val Lowe, M.D., Mayo

Robust Correctome-based Biomarkers of Degenerating Brain Systems Across the Alzheimer’s Disease Spectrum – Kamil Ugurbil, Ph.D., UMN; David Jones, M.D., Mayo

13C-Pyruvate Magnetic Resonance Spectroscopy for Pancreatic Cancer Diagnostic Imaging – Malgorzata Marjanska, Ph.D., UMN; Stephanie Carlson, M.D., Mayo

Testing Susceptibility of ‘Dirty’ Mice to Induction of Asthmatic Disease and Lung Pathology –  Stephen Jameson, Ph.D., UMN; Hirohito Kita, M.D., Mayo

Molecular Functional Biomarker in Alzheimer’s Disease –  Karen Ashe, Ph.D., M.D., UMN; Ronald Petersen, M.D., Ph.D., Mayo

Genomic and Small Molecule Screens for Regulators of Liver Steatosis – Douglas Mashek, Ph.D., UMN; Mark McNiven, Ph.D., Mayo

Precision Medicine of Aromatase Inhibitors in Post-Menopausal Women with ER+ Breast Cancer –  Michael Walters, Ph.D., UMN; Liewei Wang, M.D., Ph.D., Mayo

Astrocyte-Derived Extracellular Vesicles: Epilepsy Promoters, Repressors and Brain Stimulation – Lynne Bemis, Ph.D., UMN Duluth Campus; Gregory Worrell, M.D., Ph.D., Mayo

Activation of Guanylyl Cyclase-B as a Novel Treatment for Osteoporosis – Lincoln Potter, Ph.D., University of Minnesota; Sundeep Khosla, M.D., Mayo

Targeting Tau Phosphorylation and Missorting to Treat Alzheimer’s Disease – Dezhi Liao, Ph.D., University of Minnesota; Michelle Mielke, Ph.D., Mayo

Development of Personalized Microbiome-Based Treatment for Colorectal Cancer – Ran Blekhman, Ph.D., UMN; Khashayarsha Khazaie, Ph.D., D.Sc., Mayo

PET Agents for in Vivo Imaging of Bacterial Infections – Valerie Pierre, Ph.D., UMN; Timothy DeGrado, Ph.D., Mayo